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Jacksonville Jaguars at Cincinnati Bengals (-7.5)

Time and channel: 8:20 PM ET, NFL Network

The battle of the No. 1 overall selections from the last two drafts is an intriguing one. The Jaguars showed some signs of life in Week 3 but ultimately fell short offensively. Meanwhile, the Bengals put an ugly Week 2 loss behind them to defeat their rivals in the Steelers.

It is tough to see this game being close. Cincinnati’s defense is playing superbly right now, and Jacksonville’s offense is still getting up to speed under Urban Meyer and Trevor Lawrence. Joe Burrow and his impressive offense should be able to win comfortably.

NFL Week 4 Picks and Predictions: Bengals/Jaguars OVER 46

Sunday Week 4 free NFL picks and predictions

Washington Football Team at Atlanta Falcons (-1)

Time and channel: 1 PM ET, FOX

Sure, Washington was soundly beaten at the hands of the Buffalo Bills, but it is hard to imagine the Falcons being favorites in this one with the way they have looked thus far. Washington should be able to get its offense right against a poor Falcons defense. Meanwhile, WFT’s defense should get back on track against a mediocre Falcons offensive line.

NFL Week 4 Picks and Predictions: Washington 27, Falcons 21

Houston Texans at Buffalo Bills (-17)

Time and channel: 1 PM ET, CBS

The Buffalo Bills are 17-point favorites! No, that is not a mistake, the disparity really is that large. Even though the Texans will be coming off 10 days of rest, this game should not even be close. For Houston to have any chance, we need a WWE-style comeback to the field from Deshaun Watson in Week 4.

NFL Week 4 Picks and Predictions: Bills 35, Texans 14

Detroit Lions at Chicago Bears (-3)

Time and channel: 1 PM ET, FOX

You may look at the results from this weekend and ask yourself how the Bears are favorites. Well, had Marquise Brown been able to catch for the Ravens, we would not have needed to witness the magic from Justin Tucker that we saw against Detroit.

The Lions were not all that good in Week 3; then again, the Bears were dreadful. This game could be an ugly matchup where Chicago’s defense needs to be the difference until the Bears can get Justin Fields comfortable.

NFL Week 4 Picks and Predictions: Bears 27, Lions 21

Carolina Panthers at Dallas Cowboys (-4)

Time and channel: 1 PM ET, FOX

Until we see the Cowboys in Week 3, this game is hard to judge. The rest disparity should suit the Panthers, who will be eyeing an opportunity to complete the Texas two-step in Week 4. Carolina’s offense needs to find a way to succeed without Christian McCaffrey if the team is to keep winning.

NFL Week 4 Picks and Predictions: Cowboys 34, Panthers 20

Indianapolis Colts at Miami Dolphins (-1.5)

Time and channel: 1 PM ET, CBS

This is an early elimination game for these two franchises. With the Colts at 0-3 and the Dolphins 1-2, neither team can afford to lose. The Dolphins demonstrated their heart in Week 3, and now they have to keep their hopes alive at home in Week 4. The Colts are really struggling right now, so there are no excuses for Miami.

NFL Week 4 Picks and Predictions:  Dolphins 24 Colts 20

Cleveland Browns (-1) at Minnesota Vikings

Time and channel: 1 PM ET, CBS

In what looks set to be the early-window Game of the Week, the Browns and Vikings are both looking to continue winning ways. The Vikings’ 1-2 record doesn’t show it, but they lost by a combined 4 points in the first two weeks before an impressive victory over the Seahawks.

Meanwhile, the Browns have narrowly missed out on a 3-0 start. With the AFC North appearing wide open in 2021, Cleveland cannot afford to stumble in the coming weeks. This game should be fascinating and tell us a lot about where both franchises stand in 2021.

NFL Week 4 Picks and Predictions: Browns 27, Vikings 24

New York Giants at New Orleans Saints (-7.5)

Time and channel: 1 PM ET, FOX

The Saints were extremely impressive in going to Foxborough and defeating the Patriots. Meanwhile, the Giants played an ugly game at home to the Falcons. With everything the Saints have been through in the past month, combined with the emotion of this being a homecoming game, they should comfortably handle the Giants.

NFL Week 4 Picks and Predictions: Saints 23, Giants 16

Tennessee Titans (-7.5) at New York Jets

Time and channel: 1 PM ET, CBS

If this game is even close, the Titans will be embarrassed. In the first three weeks, the Jets have lost by a total of 50 points. Meanwhile, the Titans have recovered from a tough Week 1 loss and are now eyeing up two games against the Jets and Jaguars that they need to win handily.

NFL Week 4 Picks and Predictions: Titans 31, Jets 26

Kansas City Chiefs (-5.5) at Philadelphia Eagles

Time and channel: 1 PM ET, CBS

Not sure anyone thought we would be saying this, but this is a must-win game for the Chiefs. If they lose and the Raiders or Broncos win, Kansas City is already three games behind first place in the division.

As for the Eagles, they will be motivated by the vulnerabilities they have seen in a Chiefs defense that has already allowed 95 points this season. The Chiefs should win, but this could be closer than we expected before the season began.

NFL Week 4 Picks and Predictions: Chiefs 38, Eagles 27

Arizona Cardinals at Los Angeles Rams (-6)

Time and channel: 4:05 PM ET, FOX

After an impressive Week 1 performance, the Cardinals have been less than convincing over the last two weeks. Now, they face a Rams team that has largely been dominant, especially at home. Los Angeles should be the better team. But these NFC West battles are always tighter than expected.

NFL Week 4 Picks and Predictions: Rams 31, Cardinals 24

Seattle Seahawks at San Francisco 49ers (-3.5)

Time and channel: 4:05 PM ET, FOX

The 49ers will be devastated not to be 3-0 after a last-second loss to the Packers. Staying at home for Week 4, they should have the advantage in this one, but divisional games are always ultra-competitive. The 49ers appear to be the better team, and their running game should take over.

NFL Week 4 Picks and Predictions: 49ers 35, Seahawks 21

Baltimore Ravens at Denver Broncos (-1.5)

Time and channel: 4:25 PM ET, FOX

The Ravens have been one of the most difficult teams to predict this season. Meanwhile, the Broncos are facing their first major challenge of 2021. The game is perhaps the hardest to pick this week, but after Baltimore’s poor Week 3 performance, the lean has to be with the lines and odds towards the Broncos.

NFL Week 4 Picks and Predictions: Ravens 23 Broncos 21

Pittsburgh Steelers at Green Bay Packers (-6)

Time and channel: 4:25 PM ET, CBS

This game feels like a huge mismatch after what we saw in Week 3. The Packers underlined their credentials as one of the top teams in the NFC, while the Steelers appear to be what everyone feared they would be entering the season. It would be a surprise if this is not a comfortable Packers win in Lambeau Field.

NFL Week 4 Picks and Predictions: Packers 31, Steelers 17